Trimipramine (a Tricyclic antidepressant)

Indications

1. depressive illnesses, particularly where sedation is required

Cautions to be considered

1. cardiac diseases (arrhythmias)
2. Epilepsy
3. Pregnancy and breast feeding.
4. Elderly
5. Hepatic impairment
6. Thyroid diseases
7. Phaeochromocytoma
8. History of mania
9. Angle closure glaucoma
10. History of urinary retention

Contraindications (where you have to avoid the drug)

1. recent myocardial infarction
2. arrhythmias (particularly heart block)
3. severe liver disease

Doses

Initially 50-75 mg daily in divided doses or as a single dose at bed time, increased as necessary to 150-300 mg daily.

ELDERLY; initially 10-25 mg three times daily, maintenance half adult dose may be sufficient.

CHILD; not recommended

Preparations

1. capsules; 50 mg, green/white
2. tablet; 10 mg