Dosulepin Hydrochloride

Indications

1. Depressive illness, especially where sedation is required.

Cautions to be considered

1. cardiac diseases (arrhythmias)
2. Epilepsy
3. Pregnancy and breast feeding.
4. Elderly
5. Hepatic impairment
6. Thyroid diseases
7. Phaeochromocytoma
8. History of mania
9. Angle closure glaucoma
10. History of urinary retention

Contraindications (where you have to avoid the drug)

1. recent myocardial infarction
2. arrhythmias (particularly heart block)
3. severe liver disease

Doses

Initially 75 mg (ELDERLY 50-75 mg) daily in divided doses or as a single dose at bed time. Increased gradually as necessary to 150 mg daily (ELDERLY 75 mg may be sufficient); up to 225 mg daily in some circumstances (eg. Hospital use). CHILD not recommended.

Dosulepin preparations

1. capsule; 25 mg
2. tablets; 75 mg