Mechanism of actions of antidepressants is based on a theory which explains why depressant occurs. According to the theory, there is a low level of monoamine in the brain in depressed persons. Main monoamines found in the brain are dopamine, noradrenalin and serotonin. Even though there are lots of monoamine found in the brain, these are the main monoamine related to depression.
Therefore any chemical compound which is capable of increasing monoamine level in the brain will be an antidepressant. Followings are the main methods of increasing monoamine in the brain;
Therefore any chemical compound which is capable of increasing monoamine level in the brain will be an antidepressant. Followings are the main methods of increasing monoamine in the brain;
- prevention of reuptake of monoamine into synaptic nerve endings from synaptic cleft (tricyclic antidepressants)
- prevention of serotonin reuptake into synaptic nerve endings from synaptic cleft (SSRI)
- prevention of noradrenalin and serotonin reuptake into synaptic nerve endings from synaptic cleft (SNSRI)
- prevention of noradrenalin and serotonin reuptake into synaptic nerve endings from synaptic cleft and serotonin (5HT2A) receptor antagonists (Nefazodone, Trazodone).
- prevention of monoamine destruction (MAOI)
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