Monoamine oxidase inhibitors are used much less frequently than tricyclic and related antidepressants, or SSRIs and related antidepressants because of the dangers of dietary and drug interactions and the fact that it is easier to prescribe MAOIswhen tricyclic antidepressants have been unsuccessful than vice versa.
Phobic patients and depressed patients with atypical, hypochondriacal, or hysterical features are said to respond best to MAOIs. However, MAOIs should be tried in any patients who are refractory to treatment with other antideoressants as there is occasionally dramatic response.
MAOis inhibits monoamine oxidase, thereby causing an accumulation of amine neurotransmitters. The metabolism of some amine drugs such as interact acting sympathomimetics is also inhibited and their pressor action may be potentiated.
Other antidepressants should notbe started for 2 weeks after treatment with MAOIs has been stopped. Conversely, a MAOIs should not be started for at least 2 weeks after a previous MAOI has been stopped.
Common MAOIs are;
1. Phenelzine
2. Isocarboxazid
3. Tranylcypromine
4. Moclobemide
Phobic patients and depressed patients with atypical, hypochondriacal, or hysterical features are said to respond best to MAOIs. However, MAOIs should be tried in any patients who are refractory to treatment with other antideoressants as there is occasionally dramatic response.
MAOis inhibits monoamine oxidase, thereby causing an accumulation of amine neurotransmitters. The metabolism of some amine drugs such as interact acting sympathomimetics is also inhibited and their pressor action may be potentiated.
Other antidepressants should notbe started for 2 weeks after treatment with MAOIs has been stopped. Conversely, a MAOIs should not be started for at least 2 weeks after a previous MAOI has been stopped.
Common MAOIs are;
1. Phenelzine
2. Isocarboxazid
3. Tranylcypromine
4. Moclobemide
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