Wednesday, March 4, 2009

Introduction to Antidepressant drugs

Antidepressant drugs are effective in the treatment of major depression ofmoderate and severe degree including major depression associated with physical illness and that following child birth; they are also effective for dysthymia (low grade chronic depression).antidepressant drugs are not generally effective in milder forms of acute depression but trial may be considered in cases of refractory to psychological treatment.

Choice of antidepressant should be based on the individualpatient’srequirements, including the presence of concomitant diseases, exixting therapy, suicide risk, and previous response to antidepressant therapy.

Either trycyclic and related antidepressants or SSRIs are generally preferred because MAOIs may be less effective and show dangerous interaction with some foods and drugs.

Patient should be reviewed every 1-2 weeks at the start of anideprassant treatment. Treatment should be continued for at least 4 weeks (6 weeks in elderly) before considering whether to switch antidepressant due to lack of efficiency.

Following remission, antidepressant treatment should be continued at the same dose for at least 4-6 months (about 12 months in elderly).

Failure to respond to an initial course of antidepressant, may be necessitate an increase in the dose, switching to a different antidepressant class, or in patient with ‘atypical’ major depression, the use of a MAOIs. Failure to respond to a second antidepressant may require the addition of an augmenting drug such as lithium or liothyronine.

3 comments:

  1. Antidepressants helps when the patient is sinking badly...but the intake of the pills should be strictly under medical guidance.If the physician stops the dosage and there is a relapse...he should be consulted and decided the dosage again...there are some who like to rely on precedence.
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  2. I got useful information from this post. I believe you have done awesome research. I take zoloft medication for treatment of depression.

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  3. Everyone knows that antidepressant, drug which use to treat depression, anxiety and other mood disorder cause side effect.

    I also know that but is here anyone in this community knows how and why causes side effect like Diarrhoea in my case.

    I am patient of MDD & GAD, treating with psychotherapy and antidepressant, Fluvoxamine 50 mg. I have started medication 10 month before. In this sort period of time I have tried half dozen of antidepressant.

    Now I am on Fluvoxamine malaete since 6 weeks. Now I am suffering Diorhhea as a side effect of it. I just want to know how and why antidepressant causes side effect ?

    Thanks for reading my question and I would be thankfull if you give meaningful answer.

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