This section covers tricyclic antidepressants(TCA) and also 1-, 2-, and 4-ring structured drugs with broadly similar properties.
These drugs are most effectve for treating moderate to severe endogenous depression associated with psychomotor and psychological changes such as loss of appetite and sleep disturbances; improvement in slepp is usually the first benefit of therapy. Since there may be an interval of 2 weeks before the antidepressant action takes place electroconvulsive treatment may be required in severe depression when delay is hazardous or intolerable.
Some tricyclic antidepressants are also effective in the management of panic disorders as well.
About 10 to 20% of patients fail to respond to tricyclic and related antidepressant drugs and inadequate dosage may be account for some these failures. It is important to use doses that are sufficiently high for effectve treatment but not so high as to cause toxic effects. Low doses should be used for initial treatment in the elderly.
TCA and related antidepressant drugs can be roughly divided into those with additional sedative properties and those which are less so. Agitated and anxious patients tent to respond best to the sedative compounds whereas withdrawn and apathetic patients will often obtain most benefit from the less sedative ones.
Common TCAs are;
1. Amitriptyline Hydrochloride
2. Amoxapine
3. Clomipramine Hydrochloride
4. Dosulepin Hydrochloride
5. Doxepin
6. Imipramine Hydrochloride
7. Lofepramine
8. Nortriprtyline
9. Trimipramine
Related antidepressants are;
1. Maprotiline Hydrochloride
2. Mianserin Hydrochloride
3. Trazodone Hydrochloride
These drugs are most effectve for treating moderate to severe endogenous depression associated with psychomotor and psychological changes such as loss of appetite and sleep disturbances; improvement in slepp is usually the first benefit of therapy. Since there may be an interval of 2 weeks before the antidepressant action takes place electroconvulsive treatment may be required in severe depression when delay is hazardous or intolerable.
Some tricyclic antidepressants are also effective in the management of panic disorders as well.
About 10 to 20% of patients fail to respond to tricyclic and related antidepressant drugs and inadequate dosage may be account for some these failures. It is important to use doses that are sufficiently high for effectve treatment but not so high as to cause toxic effects. Low doses should be used for initial treatment in the elderly.
TCA and related antidepressant drugs can be roughly divided into those with additional sedative properties and those which are less so. Agitated and anxious patients tent to respond best to the sedative compounds whereas withdrawn and apathetic patients will often obtain most benefit from the less sedative ones.
Common TCAs are;
1. Amitriptyline Hydrochloride
2. Amoxapine
3. Clomipramine Hydrochloride
4. Dosulepin Hydrochloride
5. Doxepin
6. Imipramine Hydrochloride
7. Lofepramine
8. Nortriprtyline
9. Trimipramine
Related antidepressants are;
1. Maprotiline Hydrochloride
2. Mianserin Hydrochloride
3. Trazodone Hydrochloride
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