Indications
1. depressive illness
2. nocturnal enuresis of children
Cautions to be considered
1. cardiac diseases (arrhythmias)
2. Epilepsy
3. Pregnancy and breast feeding.
4. Elderly
5. Hepatic impairment
6. Thyroid diseases
7. Phaeochromocytoma
8. History of mania
9. Angle closure glaucoma
10. History of urinary retention
Contraindications (where you have to avoid the drug)
1. recent myocardial infarction
2. arrhythmias (particularly heart block)
3. severe liver disease
Doses
1. depression
Initially up to 75 mg daily in divided doses increased gradually to 150-200 mg (up to 300 mg in hospitalized patients); up to 150 mg may be given as a single dose at bed time.
ELDERLY; initially 10 mg daily, increased gradually up to 30-50 mg daily.
CHID; not recommended for depression.
2. nocturnal enuresis
CHILD up to 7years 25 mg, 8-11 years 25-50 mg, over 11 years 50-75 mg at bed time. Maximum period of treatment (including gradual withdrawal) 3 months, full physical examination before further course.
Preparations
1. tablets, red brown, 10 mg and 25 mg.
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